Uncoupling of ATP-depletion and cell death in human dopaminergic neurons
نویسندگان
چکیده
منابع مشابه
Correlation of oxidant-induced acute ATP depletion with delayed cell death in human neuroblastoma cells.
We correlated the adenine nucleotide (AN) levels and energy charge (EC) at the end of a transient oxidative exposure to the delayed death of neuronal cells. When wild-type (WT) or Bcl-2-overexpressing (BCL-2) human neuroblastoma cells (Paju) were exposed to 250 microM H(2)O(2) for 60 min, the EC of WT cells was unchanged, but that of BCL-2 cells decreased from 0.91 +/- 0.03 to 0.67 +/- 0.02. De...
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ژورنال
عنوان ژورنال: NeuroToxicology
سال: 2012
ISSN: 0161-813X
DOI: 10.1016/j.neuro.2011.12.007